BWT (UniThermia) for Bladder cancer:
Bladder Wall Thermochemotherapy (BWT) treats non-muscle invasive bladder cancer (NMIBC) by combining uniform bladder wall hyperthermia with chemotherapy instillation.
DuoThermia for Prostatitis:
Treats chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by simultaneous hyperthermia to the prostate and bladder.
Combining heat and drugs induces a synergy creating a healing phenomena:
a) Heat selectively damages the cancer tissue (neoplastic tissue)
b) Heat increases tissue drug uptake by 3 mechanisms:
- Heat increases blood flow (more drug available to the tissue)
- Heat increases cell membrane permeability to the drug
- Heat accelerates drug metabolism (with every one centigrade over 37 centigrade metabolism increased about 50%)